Ivabradine
- 2 independent labs in 2 countries
- 1 trial, none about aging
- Human trial1
- Animals1
Outcomes
5Elastic energy stored
upin humans1
1 study
Elastic energy stored
upin humans1
Ivabradine increases elastic energy stored in humans.
“HR reduction by ivabradine increased WV and WE whereas WV/WE remained stable.”
Human trialcarotid artery5 mg BID1-weekn = 19
Adaptation of Arterial Wall Viscosity to the Short-Term Reduction of Heart Rate: Impact of Aging
Journal of the American Heart Association
Energy dissipated
upin humans1
1 study
Energy dissipated
upin humans1
Ivabradine increases energy dissipated in humans.
“HR reduction by ivabradine increased WV and WE whereas WV/WE remained stable.”
Human trialcarotid artery5 mg BID1-weekn = 19
Adaptation of Arterial Wall Viscosity to the Short-Term Reduction of Heart Rate: Impact of Aging
Journal of the American Heart Association
Body weight
no changein mice1
1 study
Body weight
no changein mice1
Ivabradine has no effect on body weight in mice (not different).
“Body weight and macroscopic findings were not different between placebo and ivabradine.”
Animalsin drinking water50 mg/kg/daylife-long
Heart rate reduction and longevity in mice
Basic research in cardiology
Lifespan
upin mice1
1 study
Lifespan
upin mice1
Ivabradine extends lifespan in mice (+6.2% median life span (p = 0.01)).
“median life span was increased by 6.2% (p = 0.01).”
Animalsin drinking water50 mg/kg/daylife-long
Heart rate reduction and longevity in mice
Basic research in cardiology
Heart rate
downin mice1
1 study
Heart rate
downin mice1
Ivabradine decreases heart rate in mice (-14% (IQR 12-15%)).
“Ivabradine reduced heart rate by 14% (median, interquartile range 12-15%) throughout life”
Animalsin drinking water50 mg/kg/daylife-long
Heart rate reduction and longevity in mice
Basic research in cardiology
Trial sponsors
University of British Columbia
1 trialEarly phase 120 people