Digoxin
In one mouse study, digoxin improves motor learning and increases motor-cortex Na/K ATPase activity and dendritic spines, without changing motor-cortex BDNF. All four findings come from one lab in one country, without independent replication; the same public and foundation funders are named across all four.
Findings from 1 paper from September 2026
- 1 lab in 1 country
- Funders: Brain Science Foundation and 6 more
- Animals1
Outcomes
4BDNF
no changein mice1
1 study
BDNF
no changein mice1
Digoxin has no effect on BDNF in mice.
“these changes occurred without a detectable increase in the brain-derived neurotrophic factor (BDNF) protein level in the motor cortex”
Animalsmotor cortex
Low-Dose Digoxin Ameliorates Age-Related Motor Learning Deficits in Mice
Neurochemical research8 Sep 2026
Dendritic spines
upin mice1
1 study
Dendritic spines
upin mice1
Digoxin increases dendritic spines in mice.
“demonstrated a selective increase in filopodia and thin-type dendritic spines, which are associated with structural remodeling”
Animalsmotor cortex
Low-Dose Digoxin Ameliorates Age-Related Motor Learning Deficits in Mice
Neurochemical research8 Sep 2026
Na/K ATPase activity
upin mice1
1 study
Na/K ATPase activity
upin mice1
Digoxin increases Na/K ATPase activity in mice.
“digoxin increased sodium-potassium ATPase (Na/K ATPase) activity in the motor cortex”
Animalsmotor cortex
Low-Dose Digoxin Ameliorates Age-Related Motor Learning Deficits in Mice
Neurochemical research8 Sep 2026
Motor learning
upin mice1
1 study
Motor learning
upin mice1
Digoxin improves motor learning in mice.
“low-dose digoxin (4 and 65 μg/kg) enhanced motor learning performance in the rotarod task, without affecting muscle strength or spontaneous locomotor activity”
Animals4 and 65 μg/kg
Low-Dose Digoxin Ameliorates Age-Related Motor Learning Deficits in Mice
Neurochemical research8 Sep 2026