INVA8001

1. INVA8001 decreases cellular senescence in mice.

   “INVA8001 treatment reduced chymase activity and was associated with decreased MC accumulation, inflammation, histological damage, fibrosis, ductular reaction, and biliary senescence in Mdr2-/- mice.”

   AnimalsMdr2 knockout miceintraperitoneally (IP)liver20 mg/kg2 weeksmales

   INVA8001, a novel and highly selective chymase inhibitor, ameliorates liver inflammation, fibrosis, and hyperplasia in Mdr2 knockout mice

   Frontiers in medicine·Jun 9, 2026

More on Cellular senescence

1. INVA8001 decreases fibrosis in mice.

   “INVA8001 treatment reduced chymase activity and was associated with decreased MC accumulation, inflammation, histological damage, fibrosis, ductular reaction, and biliary senescence in Mdr2-/- mice.”

   AnimalsMdr2 knockout miceintraperitoneally (IP)liver20 mg/kg2 weeksmales

   INVA8001, a novel and highly selective chymase inhibitor, ameliorates liver inflammation, fibrosis, and hyperplasia in Mdr2 knockout mice

   Frontiers in medicine·Jun 9, 2026

1. INVA8001 decreases inflammation in mice.

   “INVA8001 treatment reduced chymase activity and was associated with decreased MC accumulation, inflammation, histological damage, fibrosis, ductular reaction, and biliary senescence in Mdr2-/- mice.”

   AnimalsMdr2 knockout miceintraperitoneally (IP)liver20 mg/kg2 weeksmales

   INVA8001, a novel and highly selective chymase inhibitor, ameliorates liver inflammation, fibrosis, and hyperplasia in Mdr2 knockout mice

   Frontiers in medicine·Jun 9, 2026

More on Inflammation

1. INVA8001 decreases chymase activity in mice.

   “INVA8001 treatment reduced chymase activity and was associated with decreased MC accumulation, inflammation, histological damage, fibrosis, ductular reaction, and biliary senescence in Mdr2-/- mice.”

   AnimalsMdr2 knockout miceintraperitoneally (IP)liver20 mg/kg2 weeksmales

   INVA8001, a novel and highly selective chymase inhibitor, ameliorates liver inflammation, fibrosis, and hyperplasia in Mdr2 knockout mice

   Frontiers in medicine·Jun 9, 2026

More on Chymase activity