Hydroxygenkwanin

1 paper4 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

1 lab in 1 country

Animals1

Outcomes

4

CTSK

downin rats1

1 study

Hydroxygenkwanin decreases CTSK in rats.
“and cathepsin K (CTSK) (P < 0.0001 in rats; P = 0.0006 in cells).”
Animalsin ovariectomized ratsbone
Hydroxygenkwanin Identified in Rehmanniae Radix Praeparata-Corni Fructus Ameliorates Postmenopausal Osteoporosis via Modulation of the AGE-RAGE Signaling Pathway
Journal of inflammation research6 Oct 2026

AGER

downin rats1

1 study

Hydroxygenkwanin decreases AGER in rats.
“HGK treatment downregulated RAGE expression in OVX rat bone tissue (P = 0.0208)”
Animalsin ovariectomized ratsbone
Hydroxygenkwanin Identified in Rehmanniae Radix Praeparata-Corni Fructus Ameliorates Postmenopausal Osteoporosis via Modulation of the AGE-RAGE Signaling Pathway
Journal of inflammation research6 Oct 2026

Bone volume to tissue volume

upin rats1

1 study

Hydroxygenkwanin increases bone volume to tissue volume in rats (from 0.13 ± 0.02 to 0.29 ± 0.05).
“bone volume/tissue volume (BV/TV) (from 0.13 ± 0.02 to 0.29 ± 0.05)”
Animalsin ovariectomized ratsbone
Hydroxygenkwanin Identified in Rehmanniae Radix Praeparata-Corni Fructus Ameliorates Postmenopausal Osteoporosis via Modulation of the AGE-RAGE Signaling Pathway
Journal of inflammation research6 Oct 2026

More on Bone volume to tissue volume

Bone mineral density

upin rats1

1 study

Hydroxygenkwanin increases bone mineral density in rats (from 106.58 ± 11.09 mg/cm3 in the OVX group to 188.35 ± 10.18 mg/cm3 in the 10 mg/kg HGK-treated group).
“increased BMD (from 106.58 ± 11.09 mg/cm3 in the OVX group to 188.35 ± 10.18 mg/cm3 in the 10 mg/kg HGK-treated group)”
Animalsin ovariectomized ratsbone10 mg/kg
Hydroxygenkwanin Identified in Rehmanniae Radix Praeparata-Corni Fructus Ameliorates Postmenopausal Osteoporosis via Modulation of the AGE-RAGE Signaling Pathway
Journal of inflammation research6 Oct 2026

More on Bone mineral density

Latest

1 in 12 months

Journal of Inflammation Research4 h

Hydroxygenkwanin Identified in Rehmanniae Radix Praeparata-Corni Fructus Ameliorates Postmenopausal Osteoporosis via Modulation of the AGE-RAGE Signaling Pathway

Experiments in ratsPostmenopausal osteoporosis