Humanin P3S
Humanin P3S has been studied in 2 papers since 2024: 1 observational study in people, 1 review. The newest paper, May 17, 2024: “Humanin P3S, haplogroup N1b and the risk of Alzheimer's disease”.
2 papers study it4 findingsUpdated
“uncovered a unique humanin variant, P3S, specifically enriched in centenarians with the APOE4 allele.”
- 1 lab in 1 country
- Funders: National Institute on Aging and 2 more
- Humans1
What did studies of Humanin P3S find?
3Studies of Humanin P3S measured 3 outcomes; the most studied are brain pathology (1 study), amyloid beta phagocytosis (1) and amyloid-beta (1).
Brain pathology
downin mice1
1 study
Brain pathology
downin mice1
Humanin P3S decreases brain pathology in mice.
“treatment with Humanin P3S reduced APOE4-induced brain pathology”
ReviewAPOE4-induced
Humanin P3S, haplogroup N1b and the risk of Alzheimer's disease
Aging cell
amyloid beta phagocytosis
upin cells1
1 study
amyloid beta phagocytosis
upin cells1
Humanin P3S increases amyloid beta phagocytosis in cells.
“in vitro studies corroborated humanin P3S's efficacy in promoting amyloid-beta clearance.”
Cellsin vitro
Aging cell
Amyloid-beta
downin mice1
1 study
Amyloid-beta
downin mice1
Humanin P3S decreases amyloid-beta in mice.
“humanin P3S significantly attenuated brain amyloid-beta accumulation compared to the wild-type humanin.”
Animalsin APP/PS1/APOE4 micebrain
Aging cell
What is Humanin P3S linked with?
1Studies link Humanin P3S with 1 measure, most often lifespan (1 study).
Lifespan
upin humans1
1 study
Lifespan
upin humans1
Humanin P3S is associated with lifespan in humans.
“uncovered a unique humanin variant, P3S, specifically enriched in centenarians with the APOE4 allele.”
Humansin APOE4 carriers
Aging cell