Human umbilical cord blood

1. Human umbilical cord blood extends lifespan in mice (148 days vs 127 days (p < 0.001)).

   “the average age at death was: (I) 127 days for the untreated control group, (II) 138 days for the group that received 800 cGy of irradiation and congenic bone marrow (BM) and (III) 148 days for the group that received irradiation and HUCB.”

   Animalssublethal irradiation and antikiller sera34.2-35.6 x 10(6) cellsn = 11

   Human umbilical cord blood effect on sod mice (amyotrophic lateral sclerosis)

   Life sciences·26 May 2000

2. Human umbilical cord blood extends lifespan in mice (double the life span).

   “we have been able to obtain significant correction of the MRL-lpr/lpr genetic defect and double the life span”

   Animalsin MRL-lpr/lpr mice

   Effect of human cord blood transfer on survival and disease activity in MRL-lpr/lpr mice

   Clinical immunology and immunopathology·1 May 1995

1. Human umbilical cord blood induces granulomatous vasculitis in mice.

   “Granulomatous vasculitis could be identified in the animals receiving human cells”

   Animalsin MRL-lpr/lpr mice

   Effect of human cord blood transfer on survival and disease activity in MRL-lpr/lpr mice

   Clinical immunology and immunopathology·1 May 1995

More on Granulomatous vasculitis

1. Human umbilical cord blood decreases double-positive T cells in mice.

   “had mild lymphadenopathy, a decrease in double-positive T cells, and an increase in double-negative T cells”

   Animalsin MRL-lpr/lpr mice

   Effect of human cord blood transfer on survival and disease activity in MRL-lpr/lpr mice

   Clinical immunology and immunopathology·1 May 1995

More on Double-positive T cells

1. Human umbilical cord blood decreases lymphadenopathy in mice.

   “both the animals receiving congenic marrow (MRL-+/+) and the animals with human cord blood had mild lymphadenopathy”

   Animalsin MRL-lpr/lpr mice

   Effect of human cord blood transfer on survival and disease activity in MRL-lpr/lpr mice

   Clinical immunology and immunopathology·1 May 1995

More on Lymphadenopathy

1. Human umbilical cord blood lowers the risk of amyotrophic lateral sclerosis in mice.

   “large doses of HUCB mononuclear cells produced considerable delay in the onset of symptoms and death of SOD1 mice.”

   Animalssublethal irradiation and antikiller sera34.2-35.6 x 10(6) cellsn = 11

   Human umbilical cord blood effect on sod mice (amyotrophic lateral sclerosis)

   Life sciences·26 May 2000

More on Amyotrophic lateral sclerosis