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Human neural stem cells

Intervention

1 paper3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Against: findings that point the other way from most findings on the same outcome.

  • 1 lab in 2 countries
  • 1 finding against
  • Funders: California Institute for Regenerative Medicine and 1 more
  • Animals1

Outcomes

2

α-motoneuron sparing

no changein rats1downin rats1

1 study

  1. Human neural stem cells have no effect on α-motoneuron sparing in rats.

    “offered no protection to α-motoneuron pools distant from grafted lumbar segments”

    Animalspresymptomatic immunosuppressed SOD1(G93A) ratsdistant spinal cord segments

    Human neural stem cell replacement therapy for amyotrophic lateral sclerosis by spinal transplantation

    PloS one20 Aug 2012

  2. Human neural stem cells protect against α-motoneuron sparing in rats.

    “Grafting of hNSCs into the lumbar spinal cord of SOD1(G93A) rats protected α-motoneurons in the vicinity of grafted cells”

    Animalspresymptomatic immunosuppressed SOD1(G93A) ratslumbar spinal cord

    Human neural stem cell replacement therapy for amyotrophic lateral sclerosis by spinal transplantation

    PloS one20 Aug 2012

Motor function

upin rats1

1 study

  1. Human neural stem cells improve motor function in rats.

    “provided transient functional improvement”

    Animalspresymptomatic immunosuppressed SOD1(G93A) ratslumbar spinal cord

    Human neural stem cell replacement therapy for amyotrophic lateral sclerosis by spinal transplantation

    PloS one20 Aug 2012

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