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Human embryonic stem cell-derived exosomes

Intervention

1 paper3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Animals1

Outcomes

3

Physical function

upin mice1

1 study

  1. Human embryonic stem cell-derived exosomes improve physical function in mice.

    “hESC-Exos treatment remodeled the proliferative landscape of SnCs, leading to rejuvenation, as evidenced by extended lifespan, improved physical performance, and reduced aging markers.”

    Animals

    Exosomal miR-302b rejuvenates aging mice by reversing the proliferative arrest of senescent cells

    Cell metabolism15 Jan 2025

Lifespan

upin mice1

1 study

  1. Human embryonic stem cell-derived exosomes extend lifespan in mice.

    “hESC-Exos treatment remodeled the proliferative landscape of SnCs, leading to rejuvenation, as evidenced by extended lifespan, improved physical performance, and reduced aging markers.”

    Animals

    Exosomal miR-302b rejuvenates aging mice by reversing the proliferative arrest of senescent cells

    Cell metabolism15 Jan 2025

Cellular senescence

downin cells1

1 study

  1. Human embryonic stem cell-derived exosomes decrease cellular senescence in cells.

    “human embryonic stem cell-derived exosomes (hESC-Exos) reversed senescence by restoring the proliferative capacity of SnCs in vitro.”

    Cellssenescent cells

    Exosomal miR-302b rejuvenates aging mice by reversing the proliferative arrest of senescent cells

    Cell metabolism15 Jan 2025

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