Human cord blood mesenchymal stem cell conditioned medium

Intervention

1 paper studies it4 findings

Across all fields, 1 paper: none in people yet, 1 in animals

  • 1 lab in 1 country
  • Funders: Fundamental Research Funds for the Central Universities and 2 more
  • Animals1

Outcomes

3

Cellular senescence

downin cells1downin mice1

1 study
  1. Human cord blood mesenchymal stem cell conditioned medium decreases cellular senescence in cells.

    “ameliorated oxidative stress induced cellular senescence”

    Cellshydrogen peroxide-induced

    Conditioned medium from human cord blood mesenchymal stem cells attenuates age-related immune dysfunctions

    Frontiers in cell and developmental biology

  2. Human cord blood mesenchymal stem cell conditioned medium decreases cellular senescence in mice.

    “Moreover, we also found CBMSC-CM treatment significantly reduced the number of senescenT-cells in kidney tissues”

    Animalskidney

    Conditioned medium from human cord blood mesenchymal stem cells attenuates age-related immune dysfunctions

    Frontiers in cell and developmental biology

More on Cellular senescence

Naïve T-cell count

upin mice1

1 study
  1. Human cord blood mesenchymal stem cell conditioned medium increases naïve T-cell count in mice.

    “The CBMSC-CM administration also increased naïve T-cells number and restored the ratio of naïve to memory T-cells in CD4+ T-cells population”

    Animalsperipheral blood

    Conditioned medium from human cord blood mesenchymal stem cells attenuates age-related immune dysfunctions

    Frontiers in cell and developmental biology

More on Naïve T-cell count

CD4+CD25+ regulatory T cells

downin mice1

1 study
  1. Human cord blood mesenchymal stem cell conditioned medium decreases CD4+CD25+ regulatory T cells in mice.

    “CBMSC-CM) significantly reduced the population percentage of CD3−CD335+ NK and CD4+CD25+ regulatory T-cells in peripheral blood”

    Animalsperipheral blood

    Conditioned medium from human cord blood mesenchymal stem cells attenuates age-related immune dysfunctions

    Frontiers in cell and developmental biology

More on CD4+CD25+ regulatory T cells

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