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Hspc-tropic lipid nanoparticle

Hspc-tropic lipid nanoparticle has been studied in 1 paper since 2026: none in people yet, 1 in animals; 1 in the past year. The research so far is in animals. The newest story, Oct 24, 2026: “RNA delivery favored human blood stem cells in mice”.

Intervention

1 paper studies it2 findingsUpdated

1 new paper in 30 daysSee all 1

None of its findings points the other way.

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab
  • Animals1

What did studies of Hspc-tropic lipid nanoparticle find?

2

Studies of Hspc-tropic lipid nanoparticle measured 2 outcomes; the most studied are broad transcriptional perturbation (1 study) and mRNA delivery to human hematopoietic stem and progenitor cells (1).

Broad transcriptional perturbation

no changein mice1

1 study

  1. Hspc-tropic lipid nanoparticle has no effect on broad transcriptional perturbation in mice.

    “Single-cell transcriptomic and multiomic analyses revealed no broad transcriptional perturbation associated with delivery.”

    Animalshumanized NBSGW miceligand-free

    RNA delivery favored human blood stem cells in mice

    Molecular therapy : the journal of the American Society of Gene Therapy

mRNA delivery to human hematopoietic stem and progenitor cells

upin mice1

1 study

  1. Hspc-tropic lipid nanoparticle increases mRNA delivery to human hematopoietic stem and progenitor cells in mice.

    “Compared with the SM-102 LNP, the HSPC-tropic LNP achieved greater mRNA delivery to human HSPCs, while exhibiting substantially reduced hepatic delivery.”

    Animalshumanized NBSGW mice; compared with SM-102 LNPligand-freehuman hematopoietic stem and progenitor cells

    RNA delivery favored human blood stem cells in mice

    Molecular therapy : the journal of the American Society of Gene Therapy

Latest

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Molecular Therapy

RNA delivery favored human blood stem cells in mice

In humanized mice, antibody-free fat particles delivered more messenger RNA to human blood-forming stem and precursor cells than a comparison formulation.In humanized mice, antibody-free fat particles delivered more messenger RNA to human blood-forming stem and precursor cells than a comparison formulation.

Mouse studyInterventions
Paper

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