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CAS9 mRNA + B2M-targeting sgrna

CAS9 mRNA + B2M-targeting sgrna has been studied in 1 paper since 2026: none in people yet, 1 in animals; 1 in the past year. The research so far is in animals. The newest story, Oct 24, 2026: “RNA delivery favored human blood stem cells in mice”.

Intervention

1 paper studies it1 findingUpdated

1 new paper in 30 daysSee all 1

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab
  • Animals1

What did studies of CAS9 mRNA + B2M-targeting sgrna find?

1

Studies of CAS9 mRNA + B2M-targeting sgrna measured 1 outcome; the most studied are B2M expression (1 study).

B2M expression

downin mice1

1 study

  1. CAS9 mRNA + B2M-targeting sgrna decreases B2M expression in mice.

    “The LNP also enabled functional delivery of Cas9 mRNA and β2M-targeting sgRNA to human CD34+ HSPCs, resulting in efficient gene editing and reduced β2M expression.”

    Animalslipid nanoparticle-delivered Cas9 mRNA and β2M-targeting sgRNAhuman CD34+ hematopoietic stem and progenitor cells

    RNA delivery favored human blood stem cells in mice

    Molecular therapy : the journal of the American Society of Gene Therapy

More on B2M expression

Latest

Nov 2025: 0Dec 2025: 0Jan 2026: 0Feb 2026: 0Mar 2026: 0Apr 2026: 0May 2026: 0Jun 2026: 0Jul 2026: 0Aug 2026: 0Sep 2026: 0Oct 2026: 11 paper in 12 months
Molecular Therapy

RNA delivery favored human blood stem cells in mice

In humanized mice, antibody-free fat particles delivered more messenger RNA to human blood-forming stem and precursor cells than a comparison formulation.In humanized mice, antibody-free fat particles delivered more messenger RNA to human blood-forming stem and precursor cells than a comparison formulation.

Mouse studyInterventions
Paper

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