Hinokitiol

1. Hinokitiol improves motor coordination in mice.

   Animalsin rotenone-induced PD mice

   Hinokitiol as a Potential GPX4 Allosteric Modulator to Prevent Ferroptosis-mediated Neurodegeneration in Parkinson's Disease · Neurochemical research · 17 Sep 2026

1. Hinokitiol extends lifespan in flies (~ 23 days (500 ppm) and ~ 27 days (1000 ppm) vs ~ 19 days).

   Model organismsin rotenone-treated flies500 ppm and 1000 ppm

   Hinokitiol as a Potential GPX4 Allosteric Modulator to Prevent Ferroptosis-mediated Neurodegeneration in Parkinson's Disease · Neurochemical research · 17 Sep 2026

1. Hinokitiol increases GPX4 in human cells.

   Cellsin rotenone-treated SH-SY5Y cells

   Hinokitiol as a Potential GPX4 Allosteric Modulator to Prevent Ferroptosis-mediated Neurodegeneration in Parkinson's Disease · Neurochemical research · 17 Sep 2026

GPX4 →

1. Hinokitiol decreases malondialdehyde in human cells.

   Cellsin rotenone-treated SH-SY5Y cells

   Hinokitiol as a Potential GPX4 Allosteric Modulator to Prevent Ferroptosis-mediated Neurodegeneration in Parkinson's Disease · Neurochemical research · 17 Sep 2026

Malondialdehyde →

1. Hinokitiol protects against cell damage in human cells.

   Cellsin retinoic acid-differentiated SH-SY5Y cells exposed to rotenone (10 μM)25 and 50 μM

   Hinokitiol as a Potential GPX4 Allosteric Modulator to Prevent Ferroptosis-mediated Neurodegeneration in Parkinson's Disease · Neurochemical research · 17 Sep 2026