High glycemic index diet

2 papers2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

1 lab in 1 country

Human trial1

Outcomes

PREVENT equations 10-year predicted CVD risk

no changein humans1

1 study

High glycemic index diet has no effect on PREVENT equations 10-year predicted CVD risk in humans (p = 0.598).
“whereas high-GI diets had no significant difference in risk compared to the low-GI diets (p = 0.598).”
Human trialcompared to low-GI diets5 weeksn = 163
Reducing Carbohydrate Quantity Lowers 10-Year Predicted Risk of Cardiovascular Disease Using the PREVENT Equation: An Ancillary Study of the OMNICARB Trial
AHA Scientific Sessions 2025 abstract3 Nov 2025

More on PREVENT equations 10-year predicted CVD risk

Associations

Age-related macular degeneration

upin humans1

1 study

High glycemic index diet raises the risk of age-related macular degeneration in humans.
“evidence also indicates positive associations between GI and risk for type 2 diabetes, cardiovascular disease, and more recently, age-related macular degeneration (AMD) in people without diabetes.”
Reviewwithout diabetes
Dietary hyperglycemia, glycemic index and metabolic retinal diseases
Progress in retinal and eye research22 Sep 2010