High blood pressure

3 papers4 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

2 independent labs in 2 countries

Funders: National Institute on Drug Abuse and 1 more

Humans3

Outcomes

Language function

upin silico1

1 study

High blood pressure improves language function in silico (+0.08 points (95% CI: 0.01-0.14)).
“Language function could increase by 0.08 points (95% CI: 0.01‐0.14) among Black participants”
In silicoBlack participants
Population‐Level Impact of Hypertension and Diabetes on Cognitive Domains: Insights from the Health and Aging Brain Study: Health Disparities
AAIC 2025 abstract23 Dec 2025

Executive function

upin silico1

1 study

High blood pressure improves executive function in silico (+0.07 points (95% CI: 0.01-0.13)).
“For executive function, eliminating hypertension would increase scores by 0.07 points (95% CI: 0.01‐0.13) for Black participants”
In silicoBlack participants
Population‐Level Impact of Hypertension and Diabetes on Cognitive Domains: Insights from the Health and Aging Brain Study: Health Disparities
AAIC 2025 abstract23 Dec 2025

Stress myocardial blood flow

downin humans1

1 study

High blood pressure decreases stress myocardial blood flow in humans (-11% (95% CI: 8-14)).
“Having a sustained higher SBP by 10mmHg from 36 to 76 years associated with an 11% (95% CI: 8-14) lower sMBF N .”
Humansmyocardiumn = 459
Cumulative Life-course Blood Pressure Burden and Steepness of Increase Are Associated with Reduced Myocardial Perfusion in Older Age: Insights from MyoFit46
AHA Scientific Sessions 2025 abstract3 Nov 2025

Rate of bone loss

upin humans1

1 study

High blood pressure increases rate of bone loss in humans.
“the rate of bone loss at the femoral neck increased with blood pressure at baseline.”
Humansfemoral neckmean 3.5 yearsfemalesn = 3,676
High blood pressure and bone-mineral loss in elderly white women: a prospective study. Study of Osteoporotic Fractures Research Group
Lancet (London, England)18 Sep 1999