Metabolism
Liver cell patterns shifted with age and insulin resistance in mice
In five 20-month-old male mice, two weeks of a signaling protein reversed one liver-cell shift and improved insulin sensitivity compared with five controls.In five 20-month-old male mice, two weeks of a signaling protein reversed one liver-cell shift and improved insulin sensitivity compared with five controls.
Experiments in miceInsulin resistance
What changedOlder mice had a smaller share of zone 3 liver cells than young mice; insulin resistance accompanied further decreases
The catchGene-defined zones could reflect changed cell identity or location rather than cell loss