HBA1C variability

1 paper2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

1 lab in 1 country

Humans1

Associations

White matter hyperintensity volume

upin humans1

1 study

HBA1C variability is associated with white matter hyperintensity volume in humans (0.3 log-unit difference (95% CI 0.04, 0.55) per two-fold increment in SD A1c).
“and 0.3 (0.04, 0.55), 1.40 (0.38, 2.3), and 0.36 (0.02, 0.70) log-unit differences in WMH volumes, respectively”
Humansbrainn = 839
Higher visit-to-visit glucose and HbA1c variability are associated with lower gray matter and higher white matter hyperintensity volumes in older adults: The Multi-Ethnic Study of Atherosclerosis (MESA)
AHA Scientific Sessions 2025 abstract3 Nov 2025

More on White matter hyperintensity volume

Gray matter volume

downin humans1

1 study

HBA1C variability is associated with gray matter volume in humans (-0.20 SD (95% CI -0.30, -0.10) per two-fold increment in SD A1c).
“In 839 participants with 3 HbA1c measurements, two-fold increments of SD A1c , ARV A1c , and VIM A1c were associated with –0.20 (–0.30, –0.10), –0.77 (–1.20, –0.38), and –0.26 (–0.39, –0.12) SD differences in total GMV”
Humansbrainn = 839
Higher visit-to-visit glucose and HbA1c variability are associated with lower gray matter and higher white matter hyperintensity volumes in older adults: The Multi-Ethnic Study of Atherosclerosis (MESA)
AHA Scientific Sessions 2025 abstract3 Nov 2025

Latest

1 in 12 months

AHA Scientific Sessions 2025 Abstract3 Nov

Higher visit-to-visit glucose and HbA1c variability are associated with lower gray matter and higher white matter hyperintensity volumes in older adults: The Multi-Ethnic Study of Atherosclerosis (MESA)

Cohort study of 1,424 peoplePopulations

Paper

HBA1C variability

Associations

Latest

Higher visit-to-visit glucose and HbA1c variability are associated with lower gray matter and higher white matter hyperintensity volumes in older adults: The Multi-Ethnic Study of Atherosclerosis (MESA)

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