Glucose variability

1 paper2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

1 lab in 1 country

Humans1

Associations

White matter hyperintensity volume

upin humans1

1 study

Glucose variability is associated with white matter hyperintensity volume in humans (0.13 log-unit difference (95% CI 0.06, 0.19) per two-fold increment in SD FG).
“and 0.13 (0.06, 0.19), 0.13 (0.06, 0.20), and 0.16 (0.05, 0.26) log-unit differences in WMH volumes, respectively”
Humansbrainn = 1,424
Higher visit-to-visit glucose and HbA1c variability are associated with lower gray matter and higher white matter hyperintensity volumes in older adults: The Multi-Ethnic Study of Atherosclerosis (MESA)
AHA Scientific Sessions 2025 abstract3 Nov 2025

More on White matter hyperintensity volume

Gray matter volume

downin humans1

1 study

Glucose variability is associated with gray matter volume in humans (-0.08 SD (95% CI -0.11, -0.06) per two-fold increment in SD FG).
“Two-fold increments of SD FG , ARV FG , and VIM FG were associated with –0.08 (–0.11, –0.06), –0.09 (–0.12, –0.06), and –0.10 (–0.14, –0.06) SD differences in total GMV”
Humansbrainn = 1,424
Higher visit-to-visit glucose and HbA1c variability are associated with lower gray matter and higher white matter hyperintensity volumes in older adults: The Multi-Ethnic Study of Atherosclerosis (MESA)
AHA Scientific Sessions 2025 abstract3 Nov 2025

Latest

1 in 12 months

AHA Scientific Sessions 2025 Abstract3 Nov

Higher visit-to-visit glucose and HbA1c variability are associated with lower gray matter and higher white matter hyperintensity volumes in older adults: The Multi-Ethnic Study of Atherosclerosis (MESA)

Cohort study of 1,424 peoplePopulations

Paper

Glucose variability

Associations

Latest

Higher visit-to-visit glucose and HbA1c variability are associated with lower gray matter and higher white matter hyperintensity volumes in older adults: The Multi-Ethnic Study of Atherosclerosis (MESA)

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