Handgrip strength

Handgrip strength has been studied in 11 papers since 2019: 11 observational studies in people; 1 in the past year. The newest paper, Jun 1, 2026: “Handgrip strength and risk of common infections and sepsis: Two prospective cohorts with proteomic mediation analysis”.

Exposure

11 papers study it3 findingsUpdated

See all 11 papers on handgrip strength

At a glance

The findings reach people, from one lab or study. 3 independent labs in 3 countries.

“There was no suggestion of an interaction between HGS and BMI to support the healthy obese hypothesis.”
Associations Between Measures of Sarcopenic Obesity and Risk of Cardiovascular Disease and Mortality: A Cohort Study and Mendelian Randomization Analysis Using the UK BiobankJournal of the American Heart Association2019doi:10.1161/jaha.118.011638

1 of its findings points the other way.

Humans: a single group. Cells, worms or flies and mice: nothing yet.
  • 3 independent labs in 3 countries
  • 1 finding against
  • Funders: Diabetes UK and 4 more
  • Humans11

What did studies of handgrip strength find?

1

Studies of handgrip strength measured 1 outcome; the most studied are Adverse effect of obesity on outcomes (1 study).

Adverse effect of obesity on outcomes

no changein humans1

1 study
  1. Handgrip strength was not clearly linked with adverse effect of obesity on outcomes in humans (interaction with body mass index).

    “There was no suggestion of an interaction between HGS and BMI to support the healthy obese hypothesis.”

    Humansinteraction with body mass index

    Associations Between Measures of Sarcopenic Obesity and Risk of Cardiovascular Disease and Mortality: A Cohort Study and Mendelian Randomization Analysis Using the UK Biobank

    Journal of the American Heart Association

What is handgrip strength linked with?

1

Studies link handgrip strength with 1 measure, most often mortality (2 studies).

Mortality

downin humans1upin humans1−54% less likely to die

2 studies
  1. Handgrip strength is linked with a lower risk of mortality in humans (highest vs lowest tertile of handgrip strength) (53.9% less likely to die).

    “Men in the highest third of handgrip strength were 53.9% less likely to experience death than those in the lowest third.”

    Humanshighest vs lowest tertile of handgrip strengthmens

    Handgrip Strength and Mortality in Elderly Koreans: Evidence From the Korea Longitudinal Study of Ageing

    Asia-Pacific journal of public health

  2. Handgrip strength is linked with a higher risk of mortality in humans (model including all four functional measures).

    “In women, lower-body performance (HR 1.66, CI 1.15-2.41) followed by grip strength (HR 1.38, CI 1.02-1.89)”

    Humansmodel including all four functional measures15 yearsfemales

    Relative importance of four functional measures as predictors of 15-year mortality in the older Dutch population

    BMC geriatrics

Latest

Dec 2025: 0Jan 2026: 0Feb 2026: 0Mar 2026: 0Apr 2026: 0May 2026: 0Jun 2026: 1Jul 2026: 0Aug 2026: 0Sep 2026: 0Oct 2026: 0Nov 2026: 01 paper in 12 months

See all 11 papers on handgrip strength