GSK-J4

1 paper2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

1 lab in 1 country

Funders: China Postdoctoral Science Foundation and 1 more

Animals1

Outcomes

Osteogenesis

upin mice1

1 study

GSK-J4 improves osteogenesis in mice.
“restoration of H3K27me3 levels via UTX inhibition (achieved through in vivo knockout or GSK-J4 treatment) effectively prevents CIH-induced senescence, promotes osteogenesis, and alleviates bone loss”
Animalsyoung murine models with CIHbone
Epigenetic Targeting of Senescent Cells Prevents the Deleterious Effects of Obstructive Sleep Apnea on Growing Skeleton
Advanced science (Weinheim, Baden-Wurttemberg, Germany)12 Dec 2025

Cellular senescence

downin mice1

1 study

GSK-J4 prevents cellular senescence in mice.
“restoration of H3K27me3 levels via UTX inhibition (achieved through in vivo knockout or GSK-J4 treatment) effectively prevents CIH-induced senescence”
Animalsyoung murine models with CIHmetaphysis of long bones
Epigenetic Targeting of Senescent Cells Prevents the Deleterious Effects of Obstructive Sleep Apnea on Growing Skeleton
Advanced science (Weinheim, Baden-Wurttemberg, Germany)12 Dec 2025

Latest

1 in 12 months

Advanced Science13 Dec

Epigenetic Targeting of Senescent Cells Prevents the Deleterious Effects of Obstructive Sleep Apnea on Growing Skeleton

Experiments in miceCellular senescence

Paper

GSK-J4

Outcomes

Latest

Epigenetic Targeting of Senescent Cells Prevents the Deleterious Effects of Obstructive Sleep Apnea on Growing Skeleton

Related