GPX4 inhibitor

Intervention1 paper1 finding

  • Cells1

Outcomes

1

Ferroptosis

upin mouse cells1Very low certainty

1 study

  1. GPX4 inhibitor induces ferroptosis in mouse cells.

    “Interventions that target these pathways, including inhibition of the lipid peroxidation antagonist Gpx4 or elevation of dihomo-gamma-linolenic acid (DGLA), result in lytic death of senescent cells.”

    Cellsin senescent cells

    LIPID METABOLISM CONTROLS CELL FATE DECISIONS BETWEEN CELLULAR SENESCENCE AND FERROPTOSIS · GSA 2024 abstract · 31 Dec 2024

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