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Preprints.org·27 Feb

The Value of a Helping Hand

Preprint: cohort study of 29,995 peoplePopulations

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Human autophagy does not uniformly decline with age, researchers reportResearchScienceDaily and 4 more

Lilly’s retatrutide achieves 18.8% weight loss in obesity and type 2 diabetesTrialsMedical Xpress and 4 more

Physical performance declines around 35, falling 30–48% below peak by 63ResearchScienceDaily and 1 more

Trials

Fatigability of Lower Limb Muscle in Older Adults: Protective Effects of Strength Training Exercise in Old Men and WomenResults posted 13 Oct 2026, Marquette University Fisetin for Improving Vascular Function in Older Adults: A Phase II Clinical TrialPhase 2Registered 13 Oct 2026, University of Colorado, Boulder ELITE: Deep Profiling and Algorithmic Polytherapy to Map Individual Response in Healthy AgingPhase 2Registered 13 Oct 2026, Sheba Medical Center

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Mechanisms208 Interventions395 Biomarkers318 Populations527 AI & data94 Industry & policy22

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