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Gabaa-receptor signaling modulation

Intervention

1 paper studies it2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: Fondazione Cariplo and 2 more
  • Animals1

Outcomes

2

Gliosis

downin mice1

1 study

  1. Gabaa-receptor signaling modulation decreases gliosis in mice.

    “modulation of GABAA-receptor signaling completely restored glutamate levels, delayed the reactive gliosis as well as the metabolic phenotypes and expanded the lifespan of the mutants.”

    Animalsin astrocyte-specific Bmal1 knockout mice

    Deletion of astrocytic BMAL1 results in metabolic imbalance and shorter lifespan in mice

    GliaDec 13, 2019

Lifespan

upin mice1

1 study

  1. Gabaa-receptor signaling modulation extends lifespan in mice.

    “modulation of GABAA-receptor signaling completely restored glutamate levels, delayed the reactive gliosis as well as the metabolic phenotypes and expanded the lifespan of the mutants.”

    Animalsin astrocyte-specific Bmal1 knockout mice

    Deletion of astrocytic BMAL1 results in metabolic imbalance and shorter lifespan in mice

    GliaDec 13, 2019

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