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Four-factor-induced reprogramming

Intervention

2 papers study it1 finding

Across all fields, 2 papers: none in people yet, 1 in animals, 1 in cells

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funder: Agence Nationale de la Recherche
  • Animals1
  • Cells1

Outcomes

1

Markers of liver aging

downin mice1

1 study

  1. Four-factor-induced reprogramming decreases markers of liver aging in mice.

    “partial 4F epigenetic reprogramming in old mice was able to reverse several markers of liver aging only in conjunction with the depletion of p16High cells”

    Animalsin conjunction with depletion of p16High cellsliver

    p16High senescence restricts cellular plasticity during somatic cell reprogramming

    Nature cell biology

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