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Fecal microbiota transplantation from young-trained donors

Intervention

1 paper5 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funders: Agencia Estatal de Investigación and 5 more
  • Animals1

Outcomes

5

Synaptic transmission

upin mice1

1 study

  1. Fecal microbiota transplantation from young-trained donors improve synaptic transmission in mice.

    “Intact LTP was observed in YT-Tr mice at 18 months of age, whereas LTP was impaired in the Auto-Tr group.”

    Animalsin aged micehippocampus

    Fecal Microbiota Transplantation from Young-Trained Donors Improves Cognitive Function in Old Mice Through Modulation of the Gut-Brain Axis

    Aging and disease26 Dec 2024

More on Synaptic transmission

Gut permeability

downin mice1

1 study

  1. Fecal microbiota transplantation from young-trained donors decrease gut permeability in mice.

    “A significant reduction in ileal and colon permeability was detected in YT-Tr animals”

    Animalscompared to Auto-Trileum and colon

    Fecal Microbiota Transplantation from Young-Trained Donors Improves Cognitive Function in Old Mice Through Modulation of the Gut-Brain Axis

    Aging and disease26 Dec 2024

More on Gut permeability

Inflammation

downin mice1

1 study

  1. Fecal microbiota transplantation from young-trained donors decrease inflammation in mice.

    “Neuroinflammation was reduced, and synaptic plasticity modulators such as PSD-95 and FNDC5/Irisin were upregulated in the hippocampus of YT-Tr mice”

    Animalscompared to both YS-Tr and Auto-Tr groupshippocampus

    Fecal Microbiota Transplantation from Young-Trained Donors Improves Cognitive Function in Old Mice Through Modulation of the Gut-Brain Axis

    Aging and disease26 Dec 2024

More on Inflammation

Recognition and spatial memory

upin mice1

1 study

  1. Fecal microbiota transplantation from young-trained donors improve recognition and spatial memory in mice.

    “Recognition and spatial memory were significantly enhanced in YT-Tr mice compared to Auto-Tr and YS-Tr groups.”

    Animalscompared to Auto-Tr and YS-Tr groupsmales

    Fecal Microbiota Transplantation from Young-Trained Donors Improves Cognitive Function in Old Mice Through Modulation of the Gut-Brain Axis

    Aging and disease26 Dec 2024

Cognitive function

upin mice1

1 study

  1. Fecal microbiota transplantation from young-trained donors improve cognitive function in mice.

    “YT-Tr, whether performed in middle age or old age, improved cognitive function in aged mice.”

    Animalsin aged micemales

    Fecal Microbiota Transplantation from Young-Trained Donors Improves Cognitive Function in Old Mice Through Modulation of the Gut-Brain Axis

    Aging and disease26 Dec 2024

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