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Fasting diet

Intervention

2 papers7 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

  • 2 independent labs in 2 countries
  • Funder: Charité – Universitätsmedizin Berlin
  • Human trial2

Outcomes

7

Depressive symptoms

downin humans1

1 study

  1. Fasting diet decreases depressive symptoms in humans (p = 0.079).

    “depressive symptoms improved slightly at 18 months (p = 0.079).”

    Human trialrelapsing-remitting multiple sclerosis18 months

    Fasting, ketogenic, and anti-inflammatory diets in multiple sclerosis: a randomized controlled trial with 18-month follow-up

    BMC nutrition20 Aug 2025

NEFL

downin humans1

1 study

  1. Fasting diet decreases NEFL in humans (-1.94 pg/mL, p = 0.042).

    “Compared to baseline, in the FD group, Neurofilament light chain (NfL) -concentrations were lower at 9 months (-1.94 pg/mL, p = 0.042)”

    Human trialrelapsing-remitting multiple sclerosis9 months

    Fasting, ketogenic, and anti-inflammatory diets in multiple sclerosis: a randomized controlled trial with 18-month follow-up

    BMC nutrition20 Aug 2025

More on NEFL

New T2 lesions

no changein humans1

1 study

  1. Fasting diet has no effect on new T2 lesions in humans (0).

    “The primary endpoint number of new T2 lesions after 18 months did not change in any of the groups (SD 0 (0-(-1)), FD 0 (2 − 0), KD 0 (2 − 0)).”

    Human trialrelapsing-remitting multiple sclerosis18 monthsn = 81

    Fasting, ketogenic, and anti-inflammatory diets in multiple sclerosis: a randomized controlled trial with 18-month follow-up

    BMC nutrition20 Aug 2025

Central memory T cells

downin humans1

1 study

  1. Fasting diet decreases central memory T cells in humans.

    “In addition, a decrease in central memory T cells was observed.”

    Human trialbefore living kidney donationblood

    Short-term fasting before living kidney donation has an immune-modulatory effect

    Frontiers in immunology20 Feb 2025

More on Central memory T cells

Dendritic cells

upin humans1

1 study

  1. Fasting diet increases dendritic cells in humans.

    “elevation of type 1 conventional DCs (cDC1s)”

    Human trialbefore living kidney donationblood

    Short-term fasting before living kidney donation has an immune-modulatory effect

    Frontiers in immunology20 Feb 2025

More on Dendritic cells

B cell levels

upin humans1

1 study

  1. Fasting diet increases B cell levels in humans.

    “increased presence of (naïve) B cells”

    Human trialbefore living kidney donationblood

    Short-term fasting before living kidney donation has an immune-modulatory effect

    Frontiers in immunology20 Feb 2025

More on B cell levels

T cell levels

downin humans1

1 study

  1. Fasting diet decreases T cell levels in humans.

    “reducing the abundance and activation of T cells, including regulatory T cells”

    Human trialbefore living kidney donationblood

    Short-term fasting before living kidney donation has an immune-modulatory effect

    Frontiers in immunology20 Feb 2025

More on T cell levels

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