Fascia iliaca compartment block
Fascia iliaca compartment block has been studied in 5 papers since 2022: 2 trials in people, 3 reviews. The newest paper, Oct 1, 2025: “Efficacy of Regional Anesthesia in Reducing Perioperative Pain and Delirium in Elderly Patients Undergoing Hip Fracture Surgery: An Umbrella Review”.
5 papers study it11 findingsUpdated
“At 1 and 3 days after the operation, patients in group C had significantly higher VAS and lower MMES scores than those in group E.”
None of its findings points the other way.
- 3 independent labs in 1 country
- Human trial2
Studies in people
1 study gave fascia iliaca compartment block to people and measured what changed.
up: Improves cognitive function
down: Decreases post-operative pain
up: Improves hip function
Randomized trial84 people17 men and 25 women in group C, and 18 men and 24 women in group E65–85 years5 days following surgery
Patients underwent hip replacement surgery
Frontiers in aging neuroscience, Dec 5, 2022
What did studies of Fascia iliaca compartment block find?
6Studies of Fascia iliaca compartment block measured 6 outcomes; the most studied are amyloid-beta (1 study), hip function (1) and post-operative pain (1).
Amyloid-beta
downin humans1
1 study
Amyloid-beta
downin humans1
Fascia iliaca compartment block decreases amyloid-beta in humans.
“The Aβ and tau levels of patients in group C were significantly higher than those of patients in group E 1 day after the operation (P < 0.01).”
Human trial5 days following surgeryn = 84
Frontiers in aging neuroscience
Fascia iliaca compartment block decreases amyloid-beta in humans (P < 0.01 at 1 day).
“The Aβ and tau levels of patients in group C were significantly higher than those of patients in group E at 1 day after the operation (P < 0.01).”
Human trialelderly patients with high-risk hip replacementn = 84
Frontiers in aging neuroscience
Hip function
upin humans1
1 study
Hip function
upin humans1
Fascia iliaca compartment block improves hip function in humans.
“At 1 day after the operation, the Harris score of the patients in group C was significantly lower than that in group E (P < 0.05).”
Human trial5 days following surgeryn = 84
Frontiers in aging neuroscience
Fascia iliaca compartment block improves hip function in humans (P < 0.05).
“At 1 day after operation, the Harris score of patients in group C was significantly lower than that of patients in group E (P < 0.05).”
Human trialelderly patients with high-risk hip replacement1 day after operationn = 84
Frontiers in aging neuroscience
Post-operative pain
downin humans1
1 study
Post-operative pain
downin humans1
Fascia iliaca compartment block decreases post-operative pain in humans.
“At 1 and 3 days after the operation, patients in group C had significantly higher VAS scores and lower MMES scores than those in group E.”
Human trial5 days following surgeryn = 84
Frontiers in aging neuroscience
Fascia iliaca compartment block decreases post-operative pain in humans (P < 0.01 at 1 day, P < 0.05 at 3 days).
“At 1 and 3 days after the operation, patients in group C had significantly higher VAS and lower MMES scores than those in group E.”
Human trialelderly patients with high-risk hip replacementn = 84
Frontiers in aging neuroscience
Cognitive function
upin humans1
1 study
Cognitive function
upin humans1
Fascia iliaca compartment block improves cognitive function in humans.
“At 1 and 3 days after the operation, patients in group C had significantly higher VAS scores and lower MMES scores than those in group E.”
Human trial5 days following surgeryn = 84
Frontiers in aging neuroscience
Fascia iliaca compartment block improves cognitive function in humans (P < 0.01 at 1 day, P < 0.05 at 3 days).
“At 1 and 3 days after the operation, patients in group C had significantly higher VAS and lower MMES scores than those in group E.”
Human trialelderly patients with high-risk hip replacementn = 84
Frontiers in aging neuroscience
Post-operative complications
no changein humans1
1 study
Post-operative complications
no changein humans1
Fascia iliaca compartment block has no effect on post-operative complications in humans.
“No statistical difference existed.”
Human trial5 days following surgeryn = 84
Frontiers in aging neuroscience
Mortality
no changein humans1
1 study
Mortality
no changein humans1
Fascia iliaca compartment block has no effect on mortality in humans.
“Management of hip fracture pain with FICB does not markedly decrease short-term mortality.”
Reviewhip fracture
The Journal of the American Academy of Orthopaedic Surgeons
What is Fascia iliaca compartment block linked with?
1Studies link Fascia iliaca compartment block with 1 measure, most often perioperative neurocognitive disorder (1 study).
Perioperative neurocognitive disorder
downin humans1
1 study
Perioperative neurocognitive disorder
downin humans1
Fascia iliaca compartment block lowers the risk of perioperative neurocognitive disorder in humans.
“Fascia iliaca compartment block, bupivacaine, and continuous infusion of local anesthetics were found to reduce the incidence of PND.”
Reviewin older patients with hip fractures
Geriatric orthopaedic surgery & rehabilitation