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Extensive subcultivation

Intervention

1 paper1 finding

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funders: National Institute on Aging and 2 more
  • 1 of 1 finding with company ties
  • Cells1

Outcomes

1

Cell proliferation

downin human cells1

1 study

  1. Extensive subcultivation decreases cell proliferation in human cells.

    “the rate of growth in log phase and the final number of cells after a fixed period in culture diminishes as a function of continued passaging”

    Cellsduring extensive subcultivationbone marrow

    Growth kinetics, self-renewal, and the osteogenic potential of purified human mesenchymal stem cells during extensive subcultivation and following cryopreservation

    Journal of cellular biochemistry1 Feb 1997

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