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Estradiol + GHRP-2

Estradiol + GHRP-2 has been studied in 1 paper since 2000: 1 trial in people. The newest paper, Aug 1, 2000: “Oral estradiol administration modulates continuous intravenous growth hormone (GH)-releasing peptide-2-driven GH secretion in postmenopausal women”.

Intervention

1 paper studies it2 findingsUpdated

See all 1

“Combined E2 and GHRP-2 elevated the ApEn of GH secretory profiles significantly above control, thereby indicating a marked alteration of within-axis feedback control (P = 0.00033).”
Oral estradiol administration modulates continuous intravenous growth hormone (GH)-releasing peptide-2-driven GH secretion in postmenopausal womenThe Journal of clinical endocrinology and metabolism2000doi:10.1210/jcem.85.8.6729

None of its findings points the other way.

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: National Center for Advancing Translational Sciences and 4 more
  • Human trial1

Studies in people

1 study gave estradiol + GHRP-2 to people and measured what changed.

What did studies of Estradiol + GHRP-2 find?

2

Studies of Estradiol + GHRP-2 measured 2 outcomes; the most studied are 24-hour GH rhythm amplitude (1 study) and approximate entropy of GH secretory profiles (1).

24-hour GH rhythm amplitude

upin humans1

1 study

  1. Estradiol + GHRP-2 increases 24-hour GH rhythm amplitude in humans (combined treatment, synergistic) (11-fold).

    “Dual stimulation with E2 and GHRP-2 also synergistically increased the amplitude (by 11-fold, P < 10(-11))”

    Human trialcombined treatment, synergistic24 hfemalesn = 10

    Oral estradiol administration modulates continuous intravenous growth hormone (GH)-releasing peptide-2-driven GH secretion in postmenopausal women

    The Journal of clinical endocrinology and metabolism

More on 24-hour GH rhythm amplitude

Approximate entropy of GH secretory profiles

upin humans1

1 study

  1. Estradiol + GHRP-2 increases approximate entropy of GH secretory profiles in humans (combined treatment).

    “Combined E2 and GHRP-2 elevated the ApEn of GH secretory profiles significantly above control, thereby indicating a marked alteration of within-axis feedback control (P = 0.00033).”

    Human trialcombined treatment24 hfemalesn = 10

    Oral estradiol administration modulates continuous intravenous growth hormone (GH)-releasing peptide-2-driven GH secretion in postmenopausal women

    The Journal of clinical endocrinology and metabolism

More on Approximate entropy of GH secretory profiles

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