EPHA4-FC
EPHA4-FC has been studied in 1 paper since 2016: 1 observational study in people. The newest paper, Jan 6, 2016: “Activation of EphA4 and EphB2 Reverse Signaling Restores the Age-Associated Reduction of Self-Renewal, Migration, and Actin Turnover in Human Tendon Stem/Progenitor Cells”.
1 paper studies it3 findingsUpdated
None of its findings points the other way.
- 1 lab in 1 country
- Funders: Deutsche Forschungsgemeinschaft and 1 more
- Humans1
What did studies of EPHA4-FC find?
3Studies of EPHA4-FC measured 3 outcomes; the most studied are cell proliferation (1 study), actin turnover (1) and cell migration (1).
Cell proliferation
upin human cells1
1 study
Cell proliferation
upin human cells1
EPHA4-FC increases cell proliferation in human cells (Restored to levels comparable to young TSPCs).
“However, only EphA4-Fc stimulation improved A-TSPC cell proliferation to levels comparable to young-TSPC (Y-TSPC).”
Cellsaged tendon stem/progenitor cells; comparison with young tendon stem/progenitor cellsclustered proteintendon stem/progenitor cell
Frontiers in aging neuroscience
Actin turnover
upin human cells1
1 study
Actin turnover
upin human cells1
EPHA4-FC improves actin turnover in human cells.
“activation of EphA4- or EphB2-dependent reverse signaling could restore the migratory ability and normalize the actin turnover of A-TSPC.”
Cellsaged tendon stem/progenitor cellsclustered proteintendon stem/progenitor cell
Frontiers in aging neuroscience
Cell migration
upin human cells1
1 study
Cell migration
upin human cells1
EPHA4-FC improves cell migration in human cells.
“activation of EphA4- or EphB2-dependent reverse signaling could restore the migratory ability and normalize the actin turnover of A-TSPC.”
Cellsaged tendon stem/progenitor cellsclustered proteintendon stem/progenitor cell
Frontiers in aging neuroscience