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Enzyme-inducing antiseizure medications

Intervention

1 paper1 finding

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 2 countries
  • Funders: Canadian Institutes of Health Research and 1 more
  • Humans1

Outcomes

1

Cardiovascular disease

mediatesin humans1

1 study

  1. Enzyme-inducing antiseizure medications mediate cardiovascular disease in humans (24.6% mediated, 95% CI 6.5%-54.6%).

    “The proportion of the effect of epilepsy on new-onset CVEs was mediated as follows by each of the following variables: strong EIASM use, 24.6% (95% CI, 6.5%-54.6%)”

    Humansin people with epilepsy6 yearsn = 27,230

    Antiseizure Medications and Cardiovascular Events in Older People With Epilepsy in the Canadian Longitudinal Study on Aging

    JAMA neurology30 Sep 2024

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