Enterococcus faecium

2 papers4 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

2 independent labs in 1 country

Funder: Priority Academic Program Development of Jiangsu Higher Education Institutions

Animals1
Model organisms1

Outcomes

Lifespan

upin mice1upin worms1+22%

2 studies

Enterococcus faecium extends lifespan in worms (+22.4%).
“significantly extended lifespan by 22.4% compared to the control.”
Model organisms
Probiotic Characterization of a Novel Enterococcus faecium CPU2401 from Pickles: Unraveling Genomic Mechanisms Underlying the Combating of Oxidative Stress and Infection
Probiotics and antimicrobial proteins6 Mar 2026
Enterococcus faecium extends lifespan in mice.
“lifespan assays suggested that the E. faecium fermentation broth may contribute to lifespan extension”
Animalsin mice
Enterococcus faecium secreted the NlpC/P60 family protein to enhance host immunity and indirectly increases Akkermansia muciniphila for slowing aging
Frontiers in microbiology29 Jan 2026

Bacterial infection

downin worms1

1 study

Enterococcus faecium protects against bacterial infection in worms.
“In Caenorhabditis elegans, E. faecium CPU2401 enhanced resistance to S. Typhimurium infection”
Model organismsS. Typhimurium infection
Probiotic Characterization of a Novel Enterococcus faecium CPU2401 from Pickles: Unraveling Genomic Mechanisms Underlying the Combating of Oxidative Stress and Infection
Probiotics and antimicrobial proteins6 Mar 2026