Engineered THY1-ENRICHED apoptotic vesicles

1 paper5 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

1 lab

Animals1

Outcomes

Systemic lipid metabolism disorders

downin mice1

1 study

Engineered THY1-ENRICHED apoptotic vesicles protect against systemic lipid metabolism disorders in mice.
“restored trabecular bone mass, reduced marrow adipose tissue, and ameliorated systemic lipid metabolism disorders.”
Animals
Apoptotic vesicles rectify senile bone-fat imbalance by activating Thy1-ERK-TAZ axis
Journal of nanobiotechnology13 Dec 2025

More on Systemic lipid metabolism disorders

Marrow adipose tissue

downin mice1

1 study

Engineered THY1-ENRICHED apoptotic vesicles decrease marrow adipose tissue in mice.
“In aged mouse models, these engineered apoVs restored trabecular bone mass, reduced marrow adipose tissue, and ameliorated systemic lipid metabolism disorders.”
Animals
Apoptotic vesicles rectify senile bone-fat imbalance by activating Thy1-ERK-TAZ axis
Journal of nanobiotechnology13 Dec 2025

Trabecular bone mass

upin mice1

1 study

Engineered THY1-ENRICHED apoptotic vesicles improve trabecular bone mass in mice.
“In aged mouse models, these engineered apoVs restored trabecular bone mass, reduced marrow adipose tissue, and ameliorated systemic lipid metabolism disorders.”
Animals
Apoptotic vesicles rectify senile bone-fat imbalance by activating Thy1-ERK-TAZ axis
Journal of nanobiotechnology13 Dec 2025

Adipogenesis

downin cells1

1 study

Engineered THY1-ENRICHED apoptotic vesicles decrease adipogenesis in cells.
“significantly enhanced osteogenesis and suppressed adipogenesis in recipient MSCs by activating the Thy1-ERK-TAZ signaling axis.”
Cellsin recipient MSCs
Apoptotic vesicles rectify senile bone-fat imbalance by activating Thy1-ERK-TAZ axis
Journal of nanobiotechnology13 Dec 2025

Osteogenesis

upin cells1

1 study

Engineered THY1-ENRICHED apoptotic vesicles increase osteogenesis in cells.
“Engineered Thy1-enriched apoVs, produced through magnetic-activated sorting and protein corona technology, significantly enhanced osteogenesis and suppressed adipogenesis in recipient MSCs”
Cellsin recipient MSCs
Apoptotic vesicles rectify senile bone-fat imbalance by activating Thy1-ERK-TAZ axis
Journal of nanobiotechnology13 Dec 2025

Latest

1 in 12 months

Journal of Nanobiotechnology14 Dec

Apoptotic vesicles rectify senile bone-fat imbalance by activating Thy1-ERK-TAZ axis

Experiments in miceBones and joints

Paper

Engineered THY1-ENRICHED apoptotic vesicles

Outcomes

Latest

Apoptotic vesicles rectify senile bone-fat imbalance by activating Thy1-ERK-TAZ axis

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