Elevated body mass index

2 papers2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

2 independent labs in 2 countries

Humans1
In silico1

Outcomes

Atrial fibrillation and flutter DALY rate

upin humans1

1 study

Elevated body mass index increases atrial fibrillation and flutter DALY rate in humans (AAPC 3.46% (95% CI: 3.44–3.48), p<0.001).
“Among the total population, the AAPC for high BMI was 3.46% (95% CI: 3.44–3.48)”
Humansattributable to high BMI
Trends in Atrial Fibrillation and Flutter Disability Adjusted Life Year Rates Attributable to Metabolic Risk Factors in The United States: An Analysis of the Global Burden of Disease, 1990-2021
AHA Scientific Sessions 2025 abstract3 Nov 2025

Associations

Uterine cancer

upin humans1

1 study

Elevated body mass index raises the risk of uterine cancer in humans.
“consistent global rise in the burden of uterine cancer attributable to elevated BMI (≥25 kg/m 2 ) over the last three decades”
HumansBMI >= 25 kg/m2
Causal impact of obesity class stratification and endometrial cancer subtypes: an integrated Mendelian randomization and Global Burden of Disease Study 2021 analysis
International journal of surgery (London, England)1 Jul 2025