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Electroencephalography-guided anesthetic administration

Intervention

1 paper3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funders: National Heart, Lung, and Blood Institute and 2 more
  • Human trial1

Outcomes

3

Electroencephalogram suppression

downin humans1

1 study

  1. Electroencephalography-guided anesthetic administration decreases electroencephalogram suppression in humans (7 vs 13 minutes; difference, -6.0 [95% CI, -9.9 to -2.1]).

    “median cumulative time with EEG suppression was significantly less (7 vs 13 minutes; difference, -6.0 [95% CI, -9.9 to -2.1])”

    Human trialundergoing major surgeryn = 1,213

    Effect of Electroencephalography-Guided Anesthetic Administration on Postoperative Delirium Among Older Adults Undergoing Major Surgery: The ENGAGES Randomized Clinical Trial

    JAMA5 Feb 2019

More on Electroencephalogram suppression

Volatile anesthetic concentration

downin humans1

1 study

  1. Electroencephalography-guided anesthetic administration decreases volatile anesthetic concentration in humans (0.69 vs 0.80 MAC; difference, -0.11 [95% CI, -0.13 to -0.10]).

    “Median end-tidal volatile anesthetic concentration was significantly lower in the guided group than the usual care group (0.69 vs 0.80 minimum alveolar concentration; difference, -0.11 [95% CI, -0.13 to -0.10)”

    Human trialundergoing major surgeryn = 1,213

    Effect of Electroencephalography-Guided Anesthetic Administration on Postoperative Delirium Among Older Adults Undergoing Major Surgery: The ENGAGES Randomized Clinical Trial

    JAMA5 Feb 2019

More on Volatile anesthetic concentration

Postoperative delirium

no changein humans1

1 study

  1. Electroencephalography-guided anesthetic administration has no effect on postoperative delirium in humans (difference, 3.0% [95% CI, -2.0% to 8.0%]; P = .22).

    “delirium during postoperative days 1 to 5 occurred in 157 of 604 patients (26.0%) in the guided group and 140 of 609 patients (23.0%) in the usual care group”

    Human trialundergoing major surgeryn = 1,213

    Effect of Electroencephalography-Guided Anesthetic Administration on Postoperative Delirium Among Older Adults Undergoing Major Surgery: The ENGAGES Randomized Clinical Trial

    JAMA5 Feb 2019

More on Postoperative delirium

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