Diet and lifestyle intervention

2 papers3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

1 lab in 1 country

Human trial2

Outcomes

Triglyceride

downin humans1

1 study

Diet and lifestyle intervention decreases triglyceride in humans (-25% (p=0.009)).
“and mean triglycerides (-25%, p=0.009).”
Human trial8-weekmalesn = 43
Potential reversal of epigenetic age using a diet and lifestyle intervention: a pilot randomized clinical trial
Aging12 Apr 2021