Diabetes prevention program

9 papers5 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

2 independent labs

Funders: National Institute of Diabetes and Digestive and Kidney Diseases and 3 more

Human trial6
Humans3

Outcomes

Body mass index

no changein humans1

1 study

Diabetes prevention program has no effect on body mass index in humans (27.8 vs 28.3, p=0.99).
“BMI was similar between Tx and Cn at baseline (28.3 vs 29.0, p=0.98) and did not significantly differ at follow-up (27.8 vs 28.3, p=0.99).”
Human trialat risk for diabetes (BMI≥25 kg/m2 [≥23 if Asian])9 monthsn = 59
Impact of a Student-Focused Version of the Diabetes Prevention Program on Lifestyle—Results from a Pilot Randomized Trial
ADA Scientific Sessions 2025 abstract13 Jun 2025

Upstream

Shared decision making

upin humans1

1 study

Shared decision making increases diabetes prevention program in humans.
“Intervention participants were more likely to initiate the DPP (OR 2.95, 1.47-5.89, p=0.002)”
Human trial12 monthsfemalesn = 247
A Randomized Trial of Shared-Decision Making for Type 2 Diabetes Prevention in Women with a History of Gestational Diabetes
ADA Scientific Sessions 2026 abstract5 Jun 2026

Funding

10 grants since 2022

National Institute of Diabetes and Digestive and Kidney DiseasesUS$6.2mNational Institute on AgingUS$70.2mNational Heart, Lung, and Blood InstituteUS$587.7k