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Diabenol

Intervention

2 papers8 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

  • 2 independent labs in 1 country
  • Animals2

Outcomes

6

Lifespan

upin mice2

2 studies

  1. Diabenol extends lifespan in mice.

    “increased life span of all and 10% most long-living NMRI mice.”

    Animals

    Insulin in aging and cancer: antidiabetic drug Diabenol as geroprotector and anticarcinogen

    The international journal of biochemistry & cell biology1 May 2005

  2. Diabenol extends lifespan in mice.

    “increased life span of all and 10% most long-living NMRI mice”

    Animals0.1 mg/l=approx. 10 mg/kg of b.w.until natural deathfemales

    Effect of antidiabetic drug diabenol on parameters of biological age, life span and tumor development in NMRI and HER-2/neu mice

    Advances in gerontology = Uspekhi gerontologii1 Jan 2004

Carcinomas in ascending colon multiplicity

downin rats1

1 study

  1. Diabenol decreases carcinomas in ascending colon multiplicity in rats (3.1 times).

    “and by 3.1 times their multiplicity.”

    Animalsin rats exposed to 1,2-dimethylhydrazine

    Insulin in aging and cancer: antidiabetic drug Diabenol as geroprotector and anticarcinogen

    The international journal of biochemistry & cell biology1 May 2005

Spontaneous tumor incidence

downin mice1

1 study

  1. Diabenol decreases spontaneous tumor incidence in mice.

    “The treatment with Diabenol inhibited spontaneous tumor incidence and increased the mammary tumor latency in these mice.”

    Animals

    Insulin in aging and cancer: antidiabetic drug Diabenol as geroprotector and anticarcinogen

    The international journal of biochemistry & cell biology1 May 2005

Metastases

downin mice1

1 study

  1. Diabenol decreases metastases in mice.

    “slightly inhibited the incidence and decreased the size of mammary adenocarcinoma metastases into the lung”

    Animalslung0.1 mg/l=approx. 10 mg/kg of b.w.until natural deathfemales

    Effect of antidiabetic drug diabenol on parameters of biological age, life span and tumor development in NMRI and HER-2/neu mice

    Advances in gerontology = Uspekhi gerontologii1 Jan 2004

Mammary tumor latency

upin mice1

1 study

  1. Diabenol increases mammary tumor latency in mice.

    “increased the mammary tumor latency”

    Animals0.1 mg/l=approx. 10 mg/kg of b.w.until natural deathfemales

    Effect of antidiabetic drug diabenol on parameters of biological age, life span and tumor development in NMRI and HER-2/neu mice

    Advances in gerontology = Uspekhi gerontologii1 Jan 2004

Tumor incidence

downin mice1

1 study

  1. Diabenol decreases tumor incidence in mice.

    “treatment with diabenol inhibited spontaneous tumor incidence (mammary gland and lymphomas mainly)”

    Animals0.1 mg/l=approx. 10 mg/kg of b.w.until natural deathfemales

    Effect of antidiabetic drug diabenol on parameters of biological age, life span and tumor development in NMRI and HER-2/neu mice

    Advances in gerontology = Uspekhi gerontologii1 Jan 2004

Associations

1

Carcinomas in ascending colon

downin rats1

1 study

  1. Diabenol lowers the risk of carcinomas in ascending colon in rats (2.2 times).

    “decreased by 2.2 times the incidence of carcinomas in ascending colon”

    Animalsin rats exposed to 1,2-dimethylhydrazine

    Insulin in aging and cancer: antidiabetic drug Diabenol as geroprotector and anticarcinogen

    The international journal of biochemistry & cell biology1 May 2005

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