Dehydroheliotridine

1. Dehydroheliotridine shortens lifespan in rats.

   “The life-span of the rats was significantly shortened by DHH”

   Animals

   Neoplasia and chronic disease associated with the prolonged administration of dehydroheliotridine to rats

   Journal of the National Cancer Institute·1 Feb 1983

1. Dehydroheliotridine raises the risk of vascular disease in rats.

   “stimulates the earlier and more rapid development of renal and vascular diseases normally associated with aging in rats.”

   Animals

   Neoplasia and chronic disease associated with the prolonged administration of dehydroheliotridine to rats

   Journal of the National Cancer Institute·1 Feb 1983

More on Vascular disease

1. Dehydroheliotridine raises the risk of renal disease in rats.

   “DHH is responsible for some, possibly most, of the carcinogenicity of the parent pyrrolizidine alkaloids and also stimulates the earlier and more rapid development of renal and vascular diseases”

   Animals

   Neoplasia and chronic disease associated with the prolonged administration of dehydroheliotridine to rats

   Journal of the National Cancer Institute·1 Feb 1983

More on Renal disease

1. Dehydroheliotridine raises the risk of tumor in rats.

   “the incidence of tumors, excluding interstitial cell tumors, was significantly greater than that in saline-injected controls.”

   Animals

   Neoplasia and chronic disease associated with the prolonged administration of dehydroheliotridine to rats

   Journal of the National Cancer Institute·1 Feb 1983

More on Tumor