Deep anesthesia
Deep anesthesia has been studied in 2 papers since 2021: 1 trial in people, 1 review. The newest paper, Nov 6, 2023: “The effect of anesthetic depth on postoperative delirium in older adults: a systematic review and meta-analysis”.
2 papers study it6 findingsUpdated
“reduce the incidence of postoperative cognitive dysfunction (POCD) in patients after VATS lobectomy.”
None of its findings points the other way.
- 2 independent labs in 1 country
- Funders: National Key Research and Development Program of China and 1 more
- Human trial1
Studies in people
1 study gave deep anesthesia to people and measured what changed.
down: Lowers the risk of postoperative cognitive dysfunction
down: Decreases pain
Randomized trial73 peopleelderly6 h and 12 h
Older adults; after VATS lobectomy
American journal of translational research, Oct 15, 2021
What did studies of Deep anesthesia find?
5Studies of Deep anesthesia measured 5 outcomes; the most studied are cognitive function (1 study), mortality (1) and postoperative delirium (1).
Cognitive function
no changein humans1OR 1.13
1 study
Cognitive function
no changein humans1OR 1.13
Deep anesthesia has no effect on cognitive function in humans (OR 1.13, 95% CI 0.67-1.91, P = 0.64).
“and cognitive function (OR, 1.13; 95% CI, 0.67-1.91, P = 0.64, I2 = 13%, high certainty) 3 months or more after surgery between deep anesthesia and light anesthesia.”
Review3 months or more after surgery
BMC geriatrics
Mortality
no changein humans1OR 1.12
1 study
Mortality
no changein humans1OR 1.12
Deep anesthesia has no effect on mortality in humans (OR 1.12, 95% CI 0.93-1.35, P = 0.23).
“no significant was found in mortality (OR, 1.12; 95% CI, 0.93-1.35, P = 0.23, I2 = 0%, high certainty)”
Review3 months or more after surgery
BMC geriatrics
Postoperative delirium
no changein humans1OR 1.4
1 study
Postoperative delirium
no changein humans1OR 1.4
Deep anesthesia has no effect on postoperative delirium in humans (OR 1.40, 95% CI 0.63-3.08, P = 0.41).
“deep anesthesia would not increase incidence of POD when compared with the light anesthesia when 4 related studies were pooled (OR, 1.40; 95% CI, 0.63-3.08, P = 0.41”
Reviewwithin 7 days after surgery
BMC geriatrics
Pain
downin humans1
1 study
Pain
downin humans1
Deep anesthesia decreases pain in humans.
“visual analogue scale (VAS) score was lower in the observation group than in the control group at 6 h and 12 h after surgery (P < 0.05).”
Human trialafter surgery6 h and 12 h
American journal of translational research
Inflammation
downin humans1
1 study
Inflammation
downin humans1
Deep anesthesia inhibits inflammation in humans.
“inhibit the inflammatory reaction”
Human trialafter VATS lobectomy
American journal of translational research
What is Deep anesthesia linked with?
1Studies link Deep anesthesia with 1 measure, most often postoperative cognitive dysfunction (1 study).
Postoperative cognitive dysfunction
downin humans1
1 study
Postoperative cognitive dysfunction
downin humans1
Deep anesthesia lowers the risk of postoperative cognitive dysfunction in humans.
“reduce the incidence of postoperative cognitive dysfunction (POCD) in patients after VATS lobectomy.”
Human trialafter VATS lobectomy
American journal of translational research