Regional cerebral oxygen saturation

1. Permissive hypercapnia increases regional cerebral oxygen saturation in humans (left: aMD 10.64, 95% CI 8.96-12.33; right: aMD 10.16, 95% CI 8.22-12.11; both P < 0.001).

   “PHC significantly increased rSO2 relative to conventional ventilation (left: adjusted mean difference [aMD] 10.64, 95% CI 8.96-12.33; right: aMD 10.16, 95% CI 8.22-12.11; both P < 0.001)”

   Human trialnon-acute fragile brain function undergoing elective laparoscopic colorectal surgeryn = 76

   Effects of permissive hypercapnia on intraoperative cerebral oxygenation and early postoperative cognitive function in older patients with fragile brain function during the non-acute phase undergoing laparoscopic colorectal surgery: A randomized controlled trial

   Experimental gerontology·Jul 21, 2026

2. Permissive hypercapnia improves regional cerebral oxygen saturation in humans ((64.04 ± 4.11)% vs. (56.43 ± 6.54)%).

   “The intraoperative rSO2 of the PH group was considerably higher, especially 10 min after the establishment of pneumoperitoneum (t = 12.328, P < 0.05) and late during the operation [(64.04 ± 4.11)% vs. (56.43 ± 6.54)%, t = 14.778, P < 0.05].”

   Humanscerebral tissue30 daysn = 450

   Effects of permissive hypercapnia on intraoperative cerebral oxygenation and early postoperative cognitive function in elderly patients undergoing laparoscopic surgery

   Frontiers in medicine·Oct 9, 2025

3. Permissive hypercapnia improves regional cerebral oxygen saturation in humans (mean difference 4.62%, 95% CI 3.81-5.43; P < 0.001).

   “Permissive hypercapnia was associated with significantly improved intraoperative cerebral oxygenation (rSO2) compared to conventional ventilation (mean difference 4.62%, 95% CI 3.81-5.43; P < 0.001)”

   Humanslaparoscopic surgeryn = 450

   Effects of permissive hypercapnia on intraoperative cerebral oxygenation and early postoperative cognitive function in elderly patients undergoing laparoscopic surgery

   Frontiers in medicine·Oct 9, 2025

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1. Dexmedetomidine increases regional cerebral oxygen saturation in humans (P < 0.05).

   “Group A exhibited higher rSO2 values at the time of endotracheal intubation, 30 min after the start of surgery, and immediately after extubation”

   Human trialundergoing radical colon cancer surgery

   Application value of dexmedetomidine in anesthesia for elderly patients undergoing radical colon cancer surgery

   World journal of gastrointestinal surgery·Aug 27, 2024

2. Dexmedetomidine has no effect on regional cerebral oxygen saturation in humans (63.5 ± 2.52% vs. 64.2 ± 3.22%).

   “The baseline rSO2 was not significantly different between the dexmedetomidine and placebo groups (dexmedetomidine 64.9 ± 2.73% vs. placebo 64.3 ± 3.29%), and no significant difference was found after the patients regained consciousness (dexmedetomidine 63.5 ± 2.52% vs. placebo 64.2 ± 3.22%).”

   Human trial20 minutesn = 61

   Effect of dexmedetomidine on the Montreal Cognitive Assessment in older patients undergoing pulmonary surgery

   The Journal of international medical research·Sep 1, 2022

3. Dexmedetomidine has no effect on regional cerebral oxygen saturation in humans.

   “The rSO2 was not significantly different between the dexmedetomidine and placebo groups.”

   Human trialundergoing lobectomy by video-assisted thoracoscopic surgery20 minutes before anesthesia inductionn = 60

   Effect of dexmedetomidine on the Montreal Cognitive Assessment in older patients undergoing pulmonary surgery

   The Journal of international medical research·Sep 1, 2022

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