American Journal of Translational Research · Oct 15, 2021
The effect of different depths of anesthesia monitored using Narcotrend on cognitive function in elderly patients after VATS lobectomy
By Chen W, Zhong S, Ke W et al.
OBJECTIVE: The purpose of this study was to examine the effects of various depths of anesthesia monitored using Narcotrend on cognitive function in elderly patients after video-assisted thoracic surgery (VATS) lobectomy. METHODS: A total of 73 elderly patients who underwent VATS lobectomy were selected and divided into a control group (n=36) and an observation group (n=37) using a random number table. Both groups received general anesthesia. The Narcotrend index (NTI) of the control group was maintained at 50-59 and that of the observation group was maintained at 30-39. RESULTS: The heart period (HP) and mean arterial pressure (MAP) from both groups were decreased first, and then were increased during T₁-T₅; the MAP levels at T₂, T₃ , and T₄ were lower in the observation group than in the control group (P < 0.05). The propofol dosage was higher and the awake to extubation time was greater in the observation group than in the control group (P < 0.05). The visual analogue scale (VAS) score was lower in the observation group than in the control group at 6 h and 12 h after surgery (P < 0.05). The left and right regional cerebral oxygen saturation (rSO₂) at T₃ -T₄ was higher in the observation group and the cerebral oxygen extraction ratio (CERO₂) was lower in the observation group than in the control group (P < 0.05). CONCLUSION: The anesthetic depth that maintained an NTI of 30-39 as monitored using Narcotrend could improve cerebral oxygen metabolism, inhibit the inflammatory reaction, and reduce the incidence of postoperative cognitive dysfunction (POCD) in patients after VATS lobectomy.