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Cyclophosphamide + tnf

Intervention

1 paper2 findings

PubChemPubChemChEBI

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funder: National Cancer Institute
  • Animals1

Outcomes

2

Cell killing (cytotoxicity)

upin mice1

1 study

  1. Cyclophosphamide + tnf increases cell killing (cytotoxicity) in mice.

    “Splenocytes from combination-treated groups developed significantly higher activity than those from cyclophosphamide-induced immune-LTS.”

    Animalson day 120 in day 60 rechallenged immune-LTS

    Cyclophosphamide plus tumor necrosis factor-alpha chemoimmunotherapy cured mice: life-long immunity and rejection of re-implanted primary lymphoma

    International journal of cancer3 Nov 1995

More on Cell killing (cytotoxicity)

Mortality

downin mice1

1 study

  1. Cyclophosphamide + tnf protects against mortality in mice.

    “One group was re-implanted with EL4 tumor; all mice survived.”

    Animalsin immune long-term survivors at day 520

    Cyclophosphamide plus tumor necrosis factor-alpha chemoimmunotherapy cured mice: life-long immunity and rejection of re-implanted primary lymphoma

    International journal of cancer3 Nov 1995

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