bioRxiv
Blood-cell mutations had opposite effects on breast tumors in mice
As mice aged, mutations in the Dnmt3a gene prevented breast cancer progression, while mutations in the Tet2 gene drove it.As mice aged, mutations in the Dnmt3a gene prevented breast cancer progression, while mutations in the Tet2 gene drove it.
Preprint: mouse studyMechanisms
Who was studiedMice with engineered blood-cell mutations
What changedIn aging mice, Dnmt3a-mutant blood cells prevented breast cancer progression, while Tet2-mutant blood cells drove it
The catchProgression of naturally arising breast tumors was not measured; tumors were implanted