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CX3CR1HI macrophage transfer

CX3CR1HI macrophage transfer has been studied in 1 paper since 2023: none in people yet, 1 in animals. The research so far is in animals. The newest paper, Apr 21, 2023: “CX3CR1hi macrophages sustain metabolic adaptation by relieving adipose-derived stem cell senescence in visceral adipose tissue”.

Intervention

1 paper studies it2 findingsUpdated

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funder: National Natural Science Foundation of China
  • Animals1

What did studies of CX3CR1HI macrophage transfer find?

2

Studies of CX3CR1HI macrophage transfer measured 2 outcomes; the most studied are cellular senescence (1 study) and metabolic maladaptation (1).

Cellular senescence

downin mice1

1 study

  1. CX3CR1HI macrophage transfer decreases cellular senescence in mice.

    “these macrophages relieve ASC senescence by promoting the arginase1-eIF5A hypusination axis.”

    Animalsvisceral adipose tissue

    CX3CR1hi macrophages sustain metabolic adaptation by relieving adipose-derived stem cell senescence in visceral adipose tissue

    Cell reports

More on Cellular senescence

Metabolic maladaptation

downin mice1

1 study

  1. CX3CR1HI macrophage transfer decreases metabolic maladaptation in mice.

    “transferring CX3CR1hi macrophages restores ASC reservoir and triggers VAT beiging to alleviate the metabolic maladaptation.”

    Animalsin long-term overnutritionvisceral adipose tissue

    CX3CR1hi macrophages sustain metabolic adaptation by relieving adipose-derived stem cell senescence in visceral adipose tissue

    Cell reports

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