Cumulative lifespan stress

Cumulative lifespan stress mediates survival in humans (b = -0.009 [95% CI, -0.017 to -0.002]).

“Cumulative lifetime stress and the CRP-IL-6 composite, which were each higher among Black compared with White individuals, partially mediated the associations between race and mortality”

Humansn = 1,554

Cumulative Lifespan Stress, Inflammation, and Racial Disparities in Mortality Between Black and White Adults

JAMA network open·2 Jan 2026