Cross regimen
Intervention1 paper2 findings
- Humans1
Outcomes
2Mutant PPM1D clones
upin humans1Very low certainty
1 study
Mutant PPM1D clones
upin humans1Very low certainty
Cross regimen increases mutant PPM1D clones in humans.
Humanspatients undergoing CROSS (chemotherapy and radiation therapy)
Cancer treatment alters mutant selection in normal esophagus · Nature genetics · 11 Sep 2026
Mutant TP53 clones
upin humans1Very low certainty
1 study
Mutant TP53 clones
upin humans1Very low certainty
Cross regimen increases mutant TP53 clones in humans.
Humanspatients undergoing CROSS (chemotherapy and radiation therapy)
Cancer treatment alters mutant selection in normal esophagus · Nature genetics · 11 Sep 2026