Context reinstatement

2 papers2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

2 independent labs in 1 country

Funder: Deutsche Forschungsgemeinschaft

Humans1

Outcomes

Old recognition responses

upin humans1

1 study

Context reinstatement increases old recognition responses in humans.
“We found a gradual increase in old responses to both target and lure objects between different, lure, and same context conditions.”
Human trialrecognition of target and lure objectssame, different, and visually similar lure background scenes
Context reinstatement reveals preserved context memory specificity in normal aging
Preprint16 Jan 2026Preprint

Memory

upin humans1

1 study

Context reinstatement improves memory in humans (Hedges' g = 0.32).
“Overall, CR reliably enhanced memory in both age groups (Hedges' g = 0.32), with no age-related difference in effect size.”
Reviewn = 2,177
Context reinstatement effects in younger and older adults' memory: A meta-analysis
Psychology and aging12 Jan 2026