Compound 753b
1 paper2 findings
- 1 lab in 1 country
- Funders: Florida Department of Health and 4 more
- Animals1
Outcomes
2Inflammation
downin cells1
1 study
Inflammation
downin cells1
Compound 753b decreases inflammation in cells.
“753b suppresses pro-inflammatory cues from both niche and hematopoietic cells including those emanating from neutrophil progenitors”
Cellsaging
Targeting cellular senescence alleviates bone marrow aging
bioRxiv : the preprint server for biology17 Jul 2026Preprint
Cellular senescence
downin cells1
1 study
Cellular senescence
downin cells1
Compound 753b decreases cellular senescence in cells.
“pharmacologic clearance of senescent cells with the PROTAC compound 753b simultaneously targeting BCL-xL and BCL-2 reverses key secretory, transcriptional, and functional hallmarks of hematopoietic aging”
Cellsaging
Targeting cellular senescence alleviates bone marrow aging
bioRxiv : the preprint server for biology17 Jul 2026Preprint
Latest
1 in 12 monthsbioRxiv
Targeting cellular senescence alleviates bone marrow aging
Preprint: experiments in animalsInterventions