Compound 25

1. Compound 25 decreases pulmonary fibrosis in mice.

   “induces a beneficial effect in a mouse model of pulmonary fibrosis”

   Animalsmouse model of pulmonary fibrosis

   Discovery of Novel Synthetic Cyclohexene-Based Small Molecules Targeting Senescence against Age-Related Pulmonary Fibrosis

   Journal of medicinal chemistry·10 Jul 2026

More on Pulmonary fibrosis

1. Compound 25 decreases cell viability in human cells.

   “selectively reduces the viability of senescent human lung adenocarcinoma cells over proliferative cells”

   Cellssenescent human lung adenocarcinoma cells

   Discovery of Novel Synthetic Cyclohexene-Based Small Molecules Targeting Senescence against Age-Related Pulmonary Fibrosis

   Journal of medicinal chemistry·10 Jul 2026

1. Compound 25 decreases senescence-associated beta-galactosidase in human cells.

   “compound 25 (UCM-17017) that decreases β-galactosidase activity in senescent human fibroblasts”

   Cellssenescent human fibroblasts

   Discovery of Novel Synthetic Cyclohexene-Based Small Molecules Targeting Senescence against Age-Related Pulmonary Fibrosis

   Journal of medicinal chemistry·10 Jul 2026

More on Senescence-associated beta-galactosidase