AgingResearch.NewsJoin free

Complete freund's adjuvant

Intervention

2 papers3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

  • 2 independent labs in 2 countries
  • 1 finding against
  • Funders: American Diabetes Association and 1 more
  • Animals2

Outcomes

2

Lifespan

upin mice1downin rats1

2 studies

  1. Complete freund's adjuvant extends lifespan in mice (alive at 12 mo (n = 13) vs untreated died before 8 mo).

    “greatly increased the life span of NOD mice without additional therapy.”

    AnimalsNOD micen = 13

    Prevention of type I diabetes in NOD mice by adjuvant immunotherapy

    Diabetes1 May 1990

  2. Complete freund's adjuvant shortens lifespan in rats.

    “Complete Freunds' adjuvant which is among the immune-stimulating substances was found to decrease significantly the lifetime of the animals”

    Animals

    Life-span investigations for carcinogenicity of some immune-stimulating, immunodepressive and neurotropic substances in Sprague-Dawley-rats

    Zeitschrift fur Krebsforschung und klinische Onkologie. Cancer research and clinical oncology3 May 1976

Type 1 diabetes

downin mice1

1 study

  1. Complete freund's adjuvant prevents type 1 diabetes in mice.

    “single injection of complete Freund's adjuvant (CFA) given at an early age (5 wk) prevented the appearance of diabetes and greatly increased the life span of NOD mice”

    AnimalsNOD micen = 13

    Prevention of type I diabetes in NOD mice by adjuvant immunotherapy

    Diabetes1 May 1990

More on Type 1 diabetes

Latest

Related